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Reyataz

Reyataz is indicated to treat Human Immunodeficiency Virus type 1 in association with other anti-retroviral drugs. Commonly Reyataz is used with low dose Ritonavir (100 mg). For adult and pediatric patients 6 years of age and older (minimum weight 15 kg). Note that Reyataz treats but doesn't cure the HIV-1 infection.

Other names for this medication:
Atazor®

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Active Ingredient:
Atazanavir

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Description

The active compound of Reyataz is Atazanavir – an anti-retroviral agent of the protease inhibitors (PIs) class. Atazanavir is normally given once a day and doesn't require multiple doses per day. It has fewer effects on the patient's lipid profile (cholesterol levels and other lipids in blood).

Indications:

- treating HIV type 1 infection in combination with low dose Ritonavir in adults and pediatric patients 6 years of age and older.

MOA (mechanism of action):

Atazanavir is an azapeptide HIV-1 protease inhibitor (PI). Atazanavir selectively inhibits the virus-specific processing of viral Gag-Pol proteins in HIV-1 infected cells, thus averting formation of mature virions and infection of other cells. Atazanavir is not active against HIV-2.

Dosage

The recommended standard treatment is Reyataz alongside Ritonavir, which ensures optimal pharmacokinetic parameters and level of virologic suppression.

Reyataz capsules must be taken with Ritonavir and have to be taken with food.

The capsules should be swallowed whole.

Adults:

The recommended dose is 300 mg with Ritonavir 100 mg taken once daily with food.

Children 6-18 years (weighing at least 15 kg):

The recommended dose is based on body weight and should not exceed the recommended adult dose.

15-35 kg: 200 mg with Ritonavir 100 mg.

35 kg and more: 300 mg with Ritonavir 100 mg.

Pediatric patients at least 3 months of age and weighing at least 5 kg are given Atazanavir oral powder.

The withdrawal of Ritonavir from the Reyataz therapy is not recommended, but may be considered in adults at the dose of 400 mg once daily with food only under the following combined restrictive conditions: absence of prior virologic failure, undetectable viral load during the last 6 months under current regimen, viral strains not harbouring HIV resistance-associated mutations (RAMs) to current regimen.

Precautions:

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Some people who take Reyataz may experience:

- An increase in weight and in levels of blood lipids and glucose.

- Cholelithiasis (the formation of gallstones).

- Chronic kidney disease in HIV-infected patients. Regular monitoring of the renal function of patients should be maintained.

- Nephrolithiasis, that is associated with acute renal failure or renal insufficiency.

- Immune reactivation syndrome (severe immune deficiency during combination anti-retroviral therapy (CART) may lead to arousal of opportunistic infections and cause serious clinical conditions).

- Osteonecrosis (the death of bone tissue). Patients should seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.

- Rash and associated syndromes (mild-to-moderate maculopapular skin eruptions occurring within the first 3 weeks of starting therapy with Reyataz. Patients should seek medical advice if such signs and symptoms occur and should be monitored for skin reactions.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Reyataz to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Reyataz tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Reyataz in the original container. Do not use Reyataz if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Common and uncommon side effects associated with Reyataz are:

  • headache
  • vomiting
  • diarrhoea
  • abdominal pain
  • nausea
  • dyspepsia
  • fatigue (extreme tiredness)
  • peripheral neuropathy
  • allergic reaction
  • asthenia
  • weight decreased
  • weight gain
  • depression
  • disorientation
  • amnesia
  • dizziness
  • somnolence (sleepiness)
  • abnormal dream
  • syncope
  • hypertension
  • dyspnoea
  • pancreatitis
  • gastritis
  • stomatitis
  • aphthous
  • dysgeusia
  • flatulence
  • angioedema
  • alopecia
  • pruritus
  • muscle atrophy
  • arthralgia
  • myalgia
  • interstitial nephritis
  • pollakiuria
  • gynaecomastia
  • chest pain
  • malaise
  • fever
  • insomnia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Reyataz is contraindicated in patients who are allergic to Atazanavir or any of the other ingredients of Reyataz.

Do not use Reyataz in patients younger than 6 years (weight under 15 kg).

Reyataz is contraindicated in patients with severe hepatic insufficiency.

Reyataz with ritonavir is contraindicated in patients with moderate hepatic insufficiency.

Do not take Reyataz with simvastatin or lovastatin, rifampicin, PDE5 inhibitors, substrates of the CYP3A4 isoform of cytochrome P450 (quetiapine, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine), ergot alkaloids (ergotamine, dihydroergotamine, ergonovine, methylergonovine), products containing St. John’s wort,atorvastatin, other anti-retrovirals (NNRTI) like nevirapine or efavirenz, salmeterol, proton pump inhibitors, hormonal contraceptives etc.

Do not take Reyataz with Ritonavir at doses greater than 100 mg per day. The use of higher Ritonavir doses may alter the safety Atazanavir (cardiac effects, hyperbilirubinemia).

Concomitant administration of Voriconazole and Reyataz and Ritonavir is not recommended.

Do not take Reyataz/Ritonavir with glucocorticoids (fluticasone).

Do not take Reyataz if you have chronic hepatitis B or C.

Reyataz should be used with particular caution in association with medicinal products which can increase the QT interval and/or in patients with pre-existing risk factors (bradycardia, long congenital QT, electrolyte imbalances.

Reyataz should be used with particular caution in hemophiliac patients due to the possibility of increased bleeding.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Do not take Reyataz if you are pregnant or plan to have a baby without prior consulting with your healthcare provider.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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Q: What is Reyataz used for?

A: Reyataz is indicated to treat Human Immunodeficiency Virus type 1 in association with other anti-retroviral drugs. Commonly Reyataz is used with low dose Ritonavir (100 mg). For adult and pediatric patients 6 years of age and older (minimum weight 15 kg). Note that Reyataz treats but doesn't cure the HIV-1 infection.

Q: Can I have sex when taking Reyataz?

A: You should know neither Reyataz nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Can I breastfeed if I take Reyataz?

A: Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

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